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  1. #1
    Registered User CanadianKid69's Avatar
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    Supplement Company rep please explain mechanism of action for your fat burner

    Recently a certain supplement company released a fat burner that contains beta-PEA. In their literature (hypothetically lets call this literature "chemical corner") the author states that beta-PEA is prevented from being degraded in the gut by MAO by using naturally sourced MAOI. Specifically the herbs Uncaria rhynophylla and Sinofranchetia chinensis and Hordenine are mentioned. How can you claim to have significant MAO inhibition and yet not be worried about hypertensive crisis potentiated by tryamine ingestion? Especially when your product contains tyrosine which breaks down into tyramine. Can a supplement company rep provide an explaination for how this product inhibits MAO but has no potential to cause a potentially lethal hypertensive crisis?
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  2. #2
    Registered User Nsaladino's Avatar
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    "The enzyme monoamine oxidase has two main forms, type A and type B. They are coded by separate genes. MAO may be inhibited with agents that act reversibly or irreversibly; and selectively or unselectively. These categories are not absolute. MAO type-A preferentially deaminates serotonin and noradrenaline, and also non-selectively dopamine. Type B metabolises dopamine, phenylethylamine (the chocolate amphetamine) and various trace amines."

    So basically just because it poses MAOI properties doesnt mean it's going to be type A and thus may not potentiate the catecholamine-releasing effect of tyramine. Which is what you addressed as your concern.
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